PEAmium – 400 mg Palmitoylethanolamide by Awakened.Energy

PEAmium is a dietary supplement that contains palmitoylethanolamide (PEA). Palmitoylethanolamide is an emerging nutraceutical that occurs naturally in both animals and plants, including egg yolk, garden pea, soybeans, sativa, corn, tomato, tissues, and body fluids. Its effects occur via natural mechanisms in the body. PEA is a fatty substance made in body cells, mainly in and by those body cells that need this substance. The cells have enzymes that produce palmitoylethanolamide as well as enzymes that break it down into building stones for our body. PEA is produced in our body as a biological response and a repair mechanism in chronic inflammation and chronic pain.

    PEAmium does not contain chemical additives. It is 100% pure PEA.
    PEAmium is guaranteed free of stearic acid, magnesium stearate and other pharmaceutical excipients.
    PEAmium capsules do not contain sorbitol, just palmitoylethanolamide.
    PEAmium is a Gluten-free and Non-GMO formulation effective for both men and women.

About PEA - Palmitoylethanolamide

New research indicates PEA may be of interest in the management of elevated eye pressure and in preventing neurodegeneration in glaucoma. Several papers have demonstrated that alterations in the endogenous levels of PEA occur in chronic inflammation. Chronic inflammation is thought to underlie glaucoma. Here it is sold as a dietary supplement and is not offered for the treatment of any disease. 

  • PEA has been described in more than 300 scientific publications.
  • PEA was described in 1957 for the first time.
  • PEA has already been used by more than a million people all over the world.
  • PEA can be used in combination with other products without any problems.
  • PEA can be found in food such as meat, eggs, soy beans and peanuts.
  • PEA inhibits the release of both preformed and newly synthesised mast cell mediators, such as histamine and TNF-alpha.

How It Works

The primary uses of PEA focus on neuropathic pain, fibromyalgia, carpal tunnel syndrome, eye health, immune function, and multiple sclerosis. This chemical binds to special cells in the body to dampen inflammation and relieve pain. 

Health Benefits of Palmitoylethanolamide PEA

The primary uses of PEA focus on neuropathic pain, fibromyalgia, carpal tunnel syndrome, eye health, immune function, and multiple sclerosis. This chemical binds to special cells in the body to dampen inflammation and relieve pain. 

Medical research studies reported anti-inflammatory activity, pain-relieving action, neuroprotective activity, antioxidant properties, and other significant health benefits of Palmitoylethanolamide. It is a non-endocannabinoid lipid mediator responsible for a wide range of medicinal uses, such as skin conditions, pain, and neurodegenerative diseases. [1, 2]

Improve Eye Health

Palmitoylethanolamide (PEA) helps different eye condition and promote eye health. The anti-inflammatory activity of PEA improves retinal inflammation and uveitis that support overall eye health and function. It eases ocular inflammation by reducing inflammatory cell infiltration and cytokines. Plus, PEA suppresses the expression of inflammatory mediators and improves diabetic retinopathy symptoms. [2, 3]

Moreover, PEA prevents the risk of glaucoma and supports eye function by reducing intraocular pressure and improving peripheral endothelial function in hypertension patients. This protective effect lasts longer than the period of PEA consumption. [6]

Promote Brain Health

PEA shows neuroprotective properties that protect nerves and improve brain function in numerous ways. It relieves neuroinflammation and downregulates pro-apoptotic biomarkers that reduce the risk of neurodegenerative disorders and promote brain health.

By modifying the biochemistry of the brain, PEA seems to improve symptoms of several mental disorders, including depression and anxiety. The effect is notable when adding PEA to other antidepressants

Medical Research Studies
Studies reported potential anti-inflammatory and antioxidant activity of PEA. It neutralizes free radicals, prevents nerve damage, and improves the symptoms of neurodegenerative diseases. Studies in animals revealed that PEA consumption avoids cognitive deficits and increases amyloid peptides and other proteins responsible for optimal cognition and nerve function. As a result, PEA improves the symptoms of neurodegenerative disorders, including Alzheimer’s disease and Parkinsonism. [2, 3]
Moreover, combining other bioactive compounds such as luteolin flavonoid relieves oxidative stress and removes nitric oxide species, reduces apoptosis, improves nerve survival, and restores important enzymes for optimal brain function. Besides, PEA also lessens neuroinflammation, improves behavioral impairment, increases the autophagy process, and prevents motor dysfunction caused by certain neurotoxins. Thus, PEA promotes nerve function in the cerebral cortex and hippocampus that improve Alzheimer’s disease symptoms. [2, 3]
An optimal amount of PEA helps the symptoms and decreases the incidence of Multiple sclerosis. It ameliorates spasticity, improves motor deficits, and supports a neurobehavioral function that eases Multiple Sclerotic symptoms. Further, the anti-inflammatory action of PEA decreases demyelination and axonal nerve damage that help multiple sclerosis and support brain functions. Also, PEA intakes improve respiration and muscle excitability, helping Amyotrophic Lateral Sclerosis (ALS) patients and supporting their brain function. [2, 3]
Studies showed that PEA reduces the risk of brain damage caused by reduced blood flow, insufficient oxygen supply, or ischemic stroke and brain injury. It improves infarct size in brain cortical, eases blocked infiltration, suppresses expression of an inflammatory biomarker, and helps arteries occlusion. Also, studies reported that PEA consumption during brain trauma helps memory loss, decreases lesion size, relieves edema, and reduces oxidative damage. Plus, it also speeds up the recovery of spinal cord injury and improves limbic motor function. Moreover, PEA helps major depressive disorders and improves mood that potentiates brain function and supports overall health. Thus, all these brain benefits strongly recommend PEA for relieving neuroinflammation and protecting the brain cells and nerves function. [4]

Relieve Pain and Improve Discomfort

Palmitoylethanolamide possesses significant analgesic activity that relieves pain and improves hyperalgesia. 

Preliminary research shows that PEA can significantly lower the threshold of pain and improve existing discomfort. Perhaps this is the most prominent benefit of taking PEA supplements since it could be beneficial for millions of people who suffer from chronic pain. [7, 8] PEA can also help with post-surgical pain especially when the incision is large. Palmitoylethanolamide supplements help with the pain and prevent the swelling of the incision.

Diabetic neuropathy is a devastating condition that compromises the patient’s sensation and triggers severe pain, which does not improve with traditional painkillers. Fortunately, PEA seems to interfere with nerve pain, which could be very beneficial for patients with peripheral neuropathies. [14]

Medical Research Studies
PEA helps various neuropathic pain severity via its anti‐nociceptive and anti-inflammatory effects. Studies showed that PEA act on cannabinoid receptors that inhibit the generation of pain and promote comfort. Moreover, PEA relieves hyperalgesia and eases pain related to injuries. 
Further, studies reported that PEA inhibits pro-inflammatory cytokines that contribute to the pain-relieving effect. The analgesic activity of PEA involved different pathways, including the mediation of CB1 receptors, PPAR‐γ, and TRPV1 channels. PEA intake also improves chronic pain and peripheral neuropathies caused by different conditions, including diabetes and lumbosciatalgia. Thus, PEA significantly blocks pain-evoking pathways that ease discomfort and improve quality of life. [2]
Additionally, Studies showed that PEA consumption significantly reduces edema and inflammatory pain that helps discomfort and different painful conditions. Plus, in combination with other potent antioxidant agents, PEA effectively relieves viscerovisceral hyperalgesia and pain associated with osteoarthritis and irregular menstrual period. Besides, it improves the insulin level and protects the islet of Langerhans morphology that helps diabetes and reduces the risk of insulitis. Also, PEA eases symptoms of common cold and influenza. [1, 2] 

Help Inflammation and Support Immunity

Palmitoylethanolamide (PEA) strengthens the immunity system and relieves inflammation, reducing the risk of various inflammatory conditions and improving longevity.


Medical Research Studies
PEA modulates the inflammatory response, eases pain, and reduces edema mediated by pro-inflammatory cytokines such as prostaglandins, leukotrienes, tumor necrosis factor, and histamine. Studies on animals revealed that PEA relieves inflammation symptoms and improves inflammatory conditions, including inflammatory bowel diseases, cystitis, arthritis, and ulcerative colitis. In the case of ulcerative colitis, PEA suppresses the release and expression of pro‐inflammatory cytokines and helps the visible signs. [2]
Also, studies suggested that PEA provides protection against mucosal damage and slows down the progression of both inflammation and cancer. Besides, PEA also helps contact allergic dermatitis and improves atopic dermatitis and moderate pruritus symptoms that support skin health and wellness. [2, 5]

Other Health Benefits

Fibromyalgia: PEA helps patients with fibromyalgia by improving their symptoms of pain and lowering its threshold. Differently put, it will require more intense stimuli for the pain to become clinically relevant.

Multiple Sclerosis: A chronic autoimmune condition characterized by inflammation that targets myelin sheaths found in the central nervous system CNS). Adding PEA to interferon-beta1a – a common treatment for MS – significantly improves the symptoms of multiple sclerosis (MS) [9, 10]

Amyotrophic Lateral Sclerosis: ALS, is a chronic, degenerative condition that presents with progressive loss of muscle control. According to one case study, PEA intake seems to improve lung function in patients with ALS; this is extremely important since pulmonary dysfunction is one of the most feared complications of ALS. [11]

Autism: Some researchers found that adding PEA to standard treatment of autism may improve symptoms, such as irritability and hyperactivity. [12]

Carpal tunnel syndrome: Reducing pain in people with carpal tunnel syndrome is a common motive to take PEA supplementation. Research shows that this effect is most prominent with severe cases of carpal tunnel syndrome. [13]

How It Works

The primary uses of PEA focus on neuropathic pain, fibromyalgia, carpal tunnel syndrome, eye health, immune function, and multiple sclerosis. This chemical binds to special cells in the body to dampen inflammation and relieve pain. 

References

References:
1. Keppel Hesselink, J. M., de Boer, T., & Witkamp, R. F. (2013). Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold. International journal of inflammation, 2013, 151028. https://doi.org/10.1155/2013/151028
2. Petrosino, S., & Di Marzo, V. (2017). The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. British journal of pharmacology, 174(11), 1349–1365. https://doi.org/10.1111/bph.13580  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429331/
3. Beggiato, S., Tomasini, M. C., & Ferraro, L. (2019). Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease. Frontiers in pharmacology, 10, 821. https://doi.org/10.3389/fphar.2019.00821 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667638/
4. Maryam Ghazizadeh-Hashemi, Alireza Ghajar, MohammadReza Shalbafan, Fatemeh Ghazizadeh-Hashemi, Mohsen Afarideh, Farzaneh Malekpour, Ali Ghaleiha, Mehrdad Eftekhar Ardebili and Shahin Akhondzadeh, Palmitoylethanolamide as adjunctive therapy in major depressive disorder: a double-blind, randomized and placebo-controlled trial, Journal of Affective Disorders, https://doi.org/10.1016/j.jad.2018.02.057
5. De Petrocellis, L., Bisogno, T., Ligresti, A., Bifulco, M., Melck, D., & Di Marzo, V. (2002). Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundamental & clinical pharmacology, 16(4), 297–302. https://doi.org/10.1046/j.1472-8206.2002.00094.x https://pubmed.ncbi.nlm.nih.gov/12570018/
6. Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky, “Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy”, Journal of Ophthalmology, vol. 2015, Article ID 430596, 9 pages, 2015. https://doi.org/10.1155/2015/430596   

7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094513/

8. https://pubmed.ncbi.nlm.nih.gov/31113223/

9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450788/

10. https://pubmed.ncbi.nlm.nih.gov/26857391/

11. https://pubmed.ncbi.nlm.nih.gov/22998138/

12. https://pubmed.ncbi.nlm.nih.gov/29807317/

13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685977/

14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996286/